Study record

Mitochondrial-derived peptides: Antidiabetic functions and evolutionary perspectives

Kal S, Mahata S, Jati S et al. · Peptides · 2024

ReviewSeveralEvidence tier R
PubMed 38160808doi:10.1016/j.peptides.2023.171147Full text (PMC)Compare with another study

What this study reported

Reviewed how MOTS-c and other mitochondria-derived peptides are encoded in mitochondrial DNA and summarised reported associations with type 1, type 2 and gestational diabetes, with an emphasis on conservation of the peptide sequences.

Limitations

Narrative review without a systematic search; it aggregates reports across species and disease models without appraising their quality.

Study record

Annotated fields for this study
Study modelReview
Substance studiedSeveralMore than one of these is central to the paper (common for reviews).
SpeciesNot reported
System studiedNarrative review of mitochondria-derived peptides in diabetes and of their sequence conservation
PopulationNot reported
DesignNarrative review
Sample size as reportedNot reported
Control groupNot reported
Route (data field only)Not reported
Endpoints measuredmitochondrial coding of MOTS-c, humanin and SHLP1-6; reported roles in type 1, type 2 and gestational diabetes; evolutionary conservation of peptide sequences
Pathways measuredInsulin & glucose handling · Other
Research areasMetabolic · Mitochondrial biology
Evidence tierR — Review (context, not evidence)
Publication typesJournal Article, Review, Research Support, N.I.H., Extramural

Appraisal

Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.

Relevance to MOTS-c
Direct
Model applicability
n/a
Sample size
n/a
Controls
n/a
Outcome validity
n/a
Support for its own conclusion
Moderate

Provenance

  • Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
  • Annotated from the published abstract.
  • Editorial review: approved (2026-11-11).
  • Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.