Study record
Alterations in circulating mitochondrial signals at hospital admission for COPD exacerbation
Amado CA, Martín-Audera P, Agüero J et al. · Chron Respir Dis · 2023
Human obs.Endogenous MOTS-c measuredEvidence tier B
What this study reported
Measured lower serum MOTS-c in patients admitted for COPD exacerbation than in patients with stable COPD, with a reported area under the curve of 0.744 for distinguishing the two groups. MOTS-c above the group mean was reported as an independent risk factor for re-admission over one year of follow-up.
Limitations
Single-centre study with a small exacerbation group and unequal group sizes; MOTS-c sampled only at admission, so the direction of the relationship cannot be established.
Study record
| Study model | Human observational |
|---|---|
| Substance studied | Endogenous MOTS-c measuredNaturally occurring MOTS-c was measured; nothing was given. |
| Species | human |
| System studied | Serum mitochondrial peptides in patients hospitalised for COPD exacerbation and outpatients with stable COPD |
| Population | patients admitted to hospital for COPD exacerbation and outpatients with stable COPD |
| Design | Prospective cohort with case-control comparison |
| Sample size as reported | 211 participants (51 exacerbation, 160 stable COPD) |
| Control group | outpatients with stable COPD |
| Route (data field only) | Not reported |
| Endpoints measured | serum MOTS-c; serum humanin, FGF-21, GDF-15 and Romo1; diagnostic accuracy for exacerbation; re-admission during follow-up |
| Pathways measured | Not reported |
| Research areas | Lung · Mitochondrial biology |
| Evidence tier | B — Other human study |
| Publication types | Journal Article, Research Support, Non-U.S. Gov't |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- Human
- Sample size
- Small
- Controls
- Appropriate
- Outcome validity
- Surrogate
- Support for its own conclusion
- Moderate
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.