Study record
Mitochondrial-derived peptides in cardiovascular disease: Novel insights and therapeutic opportunities
Li Y, Li Z, Ren Y et al. · J Adv Res · 2024
ReviewSeveralEvidence tier R
What this study reported
Reviewed the biogenesis, types and reported functions of mitochondria-derived peptides including MOTS-c, and summarised reports that their levels are lower with ageing and in cardiovascular disease.
Limitations
Narrative review with no systematic search or quality appraisal; the summarised evidence is largely preclinical and the review does not weigh study quality.
Study record
| Study model | Review |
|---|---|
| Substance studied | SeveralMore than one of these is central to the paper (common for reviews). |
| Species | Not reported |
| System studied | Narrative review of mitochondria-derived peptides in cardiovascular disease |
| Population | Not reported |
| Design | Narrative review |
| Sample size as reported | Not reported |
| Control group | Not reported |
| Route (data field only) | Not reported |
| Endpoints measured | mitochondria-derived peptide biogenesis and types; apoptosis; inflammation; oxidative stress; reported diagnostic and treatment research in cardiovascular disease |
| Pathways measured | Apoptosis · Inflammation · Oxidative stress |
| Research areas | Cardiovascular · Mitochondrial biology |
| Evidence tier | R — Review (context, not evidence) |
| Publication types | Journal Article, Review, Research Support, Non-U.S. Gov't |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- n/a
- Sample size
- n/a
- Controls
- n/a
- Outcome validity
- n/a
- Support for its own conclusion
- Moderate
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.