Study record
The role of MOTS-c-mediated antioxidant defense in aerobic exercise alleviating diabetic myocardial injury
Tang M, Su Q, Duan Y et al. · Sci Rep · 2023
What this study reported
Compared administered MOTS-c, aerobic treadmill training and their combination in a rat model of type 2 diabetes. Reported that MOTS-c, with or without exercise, was associated with reduced myocardial ultrastructural damage and with changes in glucolipid metabolism and cardiac function in these rats, and with increased SOD and CAT and increased myocardial MOTS-c, Keap1, Nrf2 and p-AMPK protein expression; the combination reduced myocardial MDA and increased p-AMPK more than either alone.
Limitations
Group sizes and animal sex not reported in the abstract; a single chemically and diet-induced rat diabetes model; outcomes are ultrastructural and biochemical surrogates, and antioxidant markers were assessed by colorimetric methods and Western blot without blinding reported.
Study record
| Study model | Animal study (in vivo) |
|---|---|
| Substance studied | MOTS-c administeredSynthetic MOTS-c was given to cells, animals or people. |
| Species | rat |
| System studied | Rat model of type 2 diabetes induced by high-fat diet plus low-dose streptozotocin; myocardium analysed |
| Population | Not reported |
| Design | Controlled animal experiment |
| Sample size as reported | not reported |
| Control group | untreated diabetic rats; aerobic exercise training and combined MOTS-c plus exercise comparison groups |
| Route (data field only) | intraperitoneal |
| Endpoints measured | myocardial ultrastructure; cardiac function; glucolipid metabolism; myocardial MDA, SOD, GSH and CAT; MOTS-c, Keap1, Nrf2, AMPK and p-AMPK protein expression |
| Pathways measured | NRF2 / antioxidant response · AMPK signalling · Oxidative stress |
| Research areas | Cardiovascular · Metabolic · Exercise |
| Evidence tier | C — Animal in vivo |
| Publication types | Journal Article, Research Support, Non-U.S. Gov't |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- Mammalian
- Sample size
- Not reported
- Controls
- Appropriate
- Outcome validity
- Surrogate
- Support for its own conclusion
- Moderate
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.