Study record
The Role of Mitokines in Diabetic Nephropathy
Yang M, Chen W, He L et al. · Curr Med Chem · 2025
ReviewRelated mitochondrial peptideEvidence tier R
What this study reported
Reviewed mitokines, the proteins and peptides released during mitochondrial stress responses, and summarised research on them in diabetic nephropathy; the abstract does not describe MOTS-c specifically.
Limitations
Narrative review with no systematic search or quality appraisal; MOTS-c is not discussed in the available abstract, so the depth of its coverage cannot be judged.
Study record
| Study model | Review |
|---|---|
| Substance studied | Related mitochondrial peptideThe paper is mainly about another mitochondrial-derived peptide, such as humanin. |
| Species | Not reported |
| System studied | Narrative review of mitokines in diabetic nephropathy |
| Population | Not reported |
| Design | Narrative review |
| Sample size as reported | Not reported |
| Control group | Not reported |
| Route (data field only) | Not reported |
| Endpoints measured | mitokine biology; mitochondrial stress response pathways; reported roles in diabetic nephropathy |
| Pathways measured | Not reported |
| Research areas | Kidney · Metabolic · Mitochondrial biology |
| Evidence tier | R — Review (context, not evidence) |
| Publication types | Journal Article, Review |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Peripheral
- Model applicability
- n/a
- Sample size
- n/a
- Controls
- n/a
- Outcome validity
- n/a
- Support for its own conclusion
- Moderate
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.