Study record
Central and peripheral mechanism of MOTS-c attenuates pain hypersensitivity in a mice model of inflammatory pain
Wang Z, Yang L, Xu L et al. · Neurol Res · 2024
What this study reported
Reported that administered MOTS-c reduced pain-related behaviours in mice with formalin-, capsaicin-, carrageenan- and CFA-induced inflammatory pain. In the same mice, central MOTS-c was associated with lower spinal inflammatory factor release and less glial and neuronal activation, and peripheral MOTS-c with reduced inflammatory responses in hindpaw skin.
Limitations
Single mouse strain and males only; group sizes and blinding are not reported in the abstract; outcomes are reflex behaviours and marker expression rather than functional pain measures.
Study record
| Study model | Animal study (in vivo) |
|---|---|
| Substance studied | MOTS-c administeredSynthetic MOTS-c was given to cells, animals or people. |
| Species | mouse |
| System studied | Male Kunming mice with formalin-, capsaicin-, carrageenan- and CFA-induced inflammatory pain |
| Population | Not reported |
| Design | Controlled animal experiment |
| Sample size as reported | Not reported |
| Control group | vehicle-treated mice with induced inflammatory pain |
| Route (data field only) | other |
| Endpoints measured | mechanical allodynia; nocifensive behaviour; spinal inflammatory factors; glial and neuronal activation; CGRP and P2X3 nociceptive neuron activity |
| Pathways measured | Inflammation |
| Research areas | Nervous system · Inflammation & immunity |
| Evidence tier | C — Animal in vivo |
| Publication types | Journal Article |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- Mammalian
- Sample size
- Not reported
- Controls
- Appropriate
- Outcome validity
- Surrogate
- Support for its own conclusion
- Moderate
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.