Study record
MOTS-c Serum Concentration Positively Correlates with Lower-Body Muscle Strength and Is Not Related to Maximal Oxygen Uptake-A Preliminary Study
Domin R, Pytka M, Żołyński M et al. · Int J Mol Sci · 2023
What this study reported
Measured resting serum MOTS-c concentration and related it to countermovement jump performance, cardiopulmonary exercise test results and body composition in physically active healthy adults. Reported that higher serum MOTS-c correlated positively with average power and with average and maximal jump force and with overall and leg muscle mass, but showed no correlation with body fat percentage or with peak oxygen uptake.
Limitations
Small preliminary sample of 20 volunteers with a strong male predominance; cross-sectional correlational design with a single resting MOTS-c measurement and no control group; the authors describe it as preliminary and requiring replication.
Study record
| Study model | Human observational |
|---|---|
| Substance studied | Endogenous MOTS-c measuredNaturally occurring MOTS-c was measured; nothing was given. |
| Species | human |
| System studied | Physically active healthy volunteers undergoing countermovement jump tests, cardiopulmonary exercise testing and bioelectrical impedance analysis |
| Population | Physically active healthy adults not in a regular training programme or competition (median age 30 years) |
| Design | Cross-sectional correlational study |
| Sample size as reported | 20 volunteers (17 male, 3 female) |
| Control group | Not reported |
| Route (data field only) | Not reported |
| Endpoints measured | resting serum MOTS-c concentration; countermovement jump average power and force; peak oxygen uptake; muscle mass and body fat percentage |
| Pathways measured | Not reported |
| Research areas | Exercise · Skeletal muscle |
| Evidence tier | B — Other human study |
| Publication types | Journal Article |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- Human
- Sample size
- Small
- Controls
- None
- Outcome validity
- Surrogate
- Support for its own conclusion
- Weak
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.