Study record
Novel function of MOTS-c in mitochondrial remodelling contributes to its antiviral role during HBV infection
Lin C, Luo L, Xun Z et al. · Gut · 2024
What this study reported
Found that serum MOTS-c correlated inversely with HBV DNA in patients with HBV infection, with a reported area under the curve of 0.9530 for distinguishing chronic hepatitis B from healthy controls. In HBV-infected cells and mice, administered MOTS-c was associated with reduced HBV replication and with changes in MYH9-actin-mediated mitochondrial dynamics and mitochondrial biogenesis.
Limitations
The human component is cross-sectional and correlative; animal and cell results cannot be transferred to people; the proposed interaction rests on prediction software plus immunoprecipitation in a limited set of models.
Study record
| Study model | Human observational |
|---|---|
| Substance studied | SeveralMore than one of these is central to the paper (common for reviews). |
| Species | human, mouse |
| System studied | Serum MOTS-c in people with HBV infection and healthy subjects, plus HBV-infected mice and cell models |
| Population | healthy subjects and patients with HBV infection, including a clinical treatment cohort |
| Design | Case-control biomarker study with animal and cell experiments |
| Sample size as reported | 489 participants (404 with HBV infection, 85 healthy) |
| Control group | healthy subjects; untreated HBV-infected cells and mice |
| Route (data field only) | Not reported |
| Endpoints measured | serum MOTS-c; HBV DNA; diagnostic accuracy for chronic hepatitis B; HBV replication; mitochondrial biogenesis; MAVS signalling |
| Pathways measured | Other · Inflammation |
| Research areas | Liver · Mitochondrial biology · Inflammation & immunity |
| Evidence tier | B — Other human study |
| Publication types | Journal Article, Research Support, Non-U.S. Gov't |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- Human
- Sample size
- Adequate
- Controls
- Appropriate
- Outcome validity
- Surrogate
- Support for its own conclusion
- Moderate
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.