Study record

The relationship of circulating MOTS-c level with liver fibrosis and metabolic components in patients with metabolic dysfunction-associated fatty liver disease

Kirik A, Dogru T, Yanik B et al. · Eur Rev Med Pharmacol Sci · 2023

Human obs.Endogenous MOTS-c measuredEvidence tier B
PubMed 37750635doi:10.26355/eurrev_202309_33567Compare with another study

What this study reported

Measured circulating MOTS-c by ELISA in adults with metabolic dysfunction-associated fatty liver disease and in healthy controls. Found significantly lower MOTS-c levels in participants with MAFLD than in controls and in those with metabolic syndrome than in those without, and reported that MOTS-c levels correlated negatively with the presence of MAFLD, the NAFLD fibrosis score, FIB-4 and components of metabolic syndrome.

Limitations

Cross-sectional single-centre design cannot establish temporality; fatty liver defined by ultrasound and fibrosis by noninvasive scores rather than biopsy; groups differed in median age and the control group was smaller.

Study record

Annotated fields for this study
Study modelHuman observational
Substance studiedEndogenous MOTS-c measuredNaturally occurring MOTS-c was measured; nothing was given.
Specieshuman
System studiedSingle-centre cohort with liver ultrasound classification; serum MOTS-c by ELISA and noninvasive fibrosis scores
PopulationAdults with metabolic dysfunction-associated fatty liver disease and healthy controls
DesignSingle-centre cross-sectional study
Sample size as reported234 participants (150 with MAFLD, 84 healthy controls)
Control grouphealthy controls without fatty liver on ultrasound
Route (data field only)Not reported
Endpoints measuredcirculating MOTS-c level; NAFLD fibrosis score; FIB-4 score; metabolic syndrome components
Pathways measuredLipid metabolism · Insulin & glucose handling
Research areasLiver · Metabolic
Evidence tierB — Other human study
Publication typesJournal Article

Appraisal

Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.

Relevance to MOTS-c
Direct
Model applicability
Human
Sample size
Adequate
Controls
Appropriate
Outcome validity
Surrogate
Support for its own conclusion
Moderate

Provenance

  • Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
  • Annotated from the published abstract.
  • Editorial review: approved (2026-11-11).
  • Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.