Study record
Mitochondria-derived peptides in healthy ageing and therapy of age-related diseases
Dabravolski SA · Adv Protein Chem Struct Biol · 2023
What this study reported
Reviewed the eight identified mitochondrial-derived peptides, noting that MOTS-c is encoded within the 12S rRNA gene (MT-RNR1) while humanin and the small humanin-like peptides are encoded by the 16S rRNA gene. Summarised reported anti-apoptotic, anti-inflammatory and cardioprotective activities, proposed roles as metabolic sensors linked to mtDNA mutation-associated and age-associated disorders, and discussed reported associations with Alzheimer's disease, cognitive decline, macular degeneration and cataracts.
Limitations
Narrative review chapter with no stated search strategy or quality appraisal; MOTS-c is covered as one of eight peptides rather than as the main subject; discussion of interventions is forward-looking rather than evidence-graded.
Study record
| Study model | Review |
|---|---|
| Substance studied | Related mitochondrial peptideThe paper is mainly about another mitochondrial-derived peptide, such as humanin. |
| Species | Not reported |
| System studied | Published literature on the eight known mitochondrial-derived peptides and age-related disease |
| Population | Not reported |
| Design | Narrative review (book chapter) |
| Sample size as reported | Not reported |
| Control group | Not reported |
| Route (data field only) | Not reported |
| Endpoints measured | mitochondrial-derived peptide metabolic signalling; cellular and mitochondrial homeostasis; age-related disease associations |
| Pathways measured | Apoptosis · Inflammation · Other |
| Research areas | Aging · Mitochondrial biology · Metabolic · Nervous system |
| Evidence tier | R — Review (context, not evidence) |
| Publication types | Journal Article |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Indirect
- Model applicability
- n/a
- Sample size
- n/a
- Controls
- n/a
- Outcome validity
- n/a
- Support for its own conclusion
- Weak
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.