Study record
Role of MOTS-c in the regulation of bone metabolism
Yi X, Hu G, Yang Y et al. · Front Physiol · 2023
What this study reported
Reviewed reports that MOTS-c promotes osteoblast proliferation, differentiation and mineralization and inhibits osteoclast production in experimental models, and summarised tissue distribution of MOTS-c. Noted that exercise upregulates MOTS-c expression while the mechanism linking exercise to bone metabolism remains unclear, and proposed candidate molecular mechanisms.
Limitations
Narrative review with no stated search strategy or risk-of-bias assessment; draws on heterogeneous cell and animal studies; proposed mechanisms are hypothetical rather than tested.
Study record
| Study model | Review |
|---|---|
| Substance studied | SeveralMore than one of these is central to the paper (common for reviews). |
| Species | Not reported |
| System studied | Published literature on MOTS-c distribution, osteoblast and osteoclast regulation, and exercise |
| Population | Not reported |
| Design | Narrative review |
| Sample size as reported | Not reported |
| Control group | Not reported |
| Route (data field only) | Not reported |
| Endpoints measured | osteoblast proliferation and differentiation; osteoblast mineralization; osteoclast formation; bone remodelling; exercise-associated MOTS-c expression |
| Pathways measured | AMPK signalling · Other |
| Research areas | Bone · Exercise · Metabolic |
| Evidence tier | R — Review (context, not evidence) |
| Publication types | Journal Article, Review |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- n/a
- Sample size
- n/a
- Controls
- n/a
- Outcome validity
- n/a
- Support for its own conclusion
- Weak
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.