Study record
Serum MOTS-C Levels are Decreased in Obese Children and Associated with Vascular Endothelial Function
Luo YH, Xie L, Li JY et al. · Diabetes Metab Syndr Obes · 2023
What this study reported
Measured serum MOTS-c by ELISA and peripheral endothelial function by reactive hyperemia index in children. Found lower serum MOTS-c and lower reactive hyperemia index in children with obesity than in healthy children, and reported that reactive hyperemia index was independently associated with body mass index, HDL cholesterol and MOTS-c, with a mediation analysis attributing a small share of the body-mass-index-to-reactive-hyperemia-index association to MOTS-c.
Limitations
Cross-sectional design cannot establish direction of effect; single-centre paediatric sample; mediation analysis accounted for only a small proportion of the association; no MeSH indexing or further covariate detail reported in the abstract.
Study record
| Study model | Human observational |
|---|---|
| Substance studied | Endogenous MOTS-c measuredNaturally occurring MOTS-c was measured; nothing was given. |
| Species | human |
| System studied | Serum MOTS-c and peripheral arterial tonometry in children with obesity and healthy children |
| Population | Children with obesity (mean age about 8 years) and healthy children of similar age |
| Design | Cross-sectional case-control study |
| Sample size as reported | 443 children (225 with obesity, 218 healthy) |
| Control group | healthy children of similar age |
| Route (data field only) | Not reported |
| Endpoints measured | serum MOTS-c concentration; reactive hyperemia index; body mass index; HDL cholesterol |
| Pathways measured | Other |
| Research areas | Metabolic · Cardiovascular |
| Evidence tier | B — Other human study |
| Publication types | Journal Article |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- Human
- Sample size
- Adequate
- Controls
- Appropriate
- Outcome validity
- Validated biomarker
- Support for its own conclusion
- Moderate
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.