Study record
Effects of intracerebroventricular MOTS-c infusion on thyroid hormones and uncoupling proteins
Bahar MR, Tekin S, Beytur A et al. · Biol Futur · 2023
What this study reported
Measured food intake, body weight, thyroid hormones and uncoupling proteins in male Wistar rats given MOTS-c by intracerebroventricular infusion. Reported higher food consumption with no change in body weight, lower serum TSH, T3 and T4, and higher UCP1 and UCP3 levels in peripheral tissues of these rats compared with control and sham groups.
Limitations
Males only, a single rat strain and 10 animals per group; central infusion is not comparable to peripheral exposure; endpoints are hormone and protein surrogates measured at one time point with no energy-expenditure measurement.
Study record
| Study model | Animal study (in vivo) |
|---|---|
| Substance studied | MOTS-c administeredSynthetic MOTS-c was given to cells, animals or people. |
| Species | rat |
| System studied | Male Wistar Albino rats in four groups: control, sham, and two MOTS-c infusion groups; hypothalamus, blood, muscle and adipose tissue sampled |
| Population | Not reported |
| Design | Controlled animal experiment with intracerebroventricular infusion |
| Sample size as reported | 40 male Wistar Albino rats (10 per group) |
| Control group | untreated control and sham-infused rats |
| Route (data field only) | intracerebroventricular |
| Endpoints measured | food consumption; body weight; serum TSH, T3 and T4; hypothalamic TRH expression; UCP1 and UCP3 in muscle and adipose tissue |
| Pathways measured | Thermogenesis / brown fat · Other |
| Research areas | Metabolic · Nervous system |
| Evidence tier | C — Animal in vivo |
| Publication types | Journal Article |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- Mammalian
- Sample size
- Small
- Controls
- Appropriate
- Outcome validity
- Surrogate
- Support for its own conclusion
- Moderate
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.