Study record
Novel Insights into Mitochondrial DNA: Mitochondrial Microproteins and mtDNA Variants Modulate Athletic Performance and Age-Related Diseases
Kumagai H, Miller B, Kim SJ et al. · Genes (Basel) · 2023
What this study reported
Reviewed sports genetics research and mitochondrial microproteins, listing MOTS-c among ten identified mitochondrial-derived peptides alongside humanin, SHLPs 1-6, SHMOOSE and Gau. Summarised reported roles for these microproteins in regulating mitochondrial function and their proposed relevance to athletic performance and age-related disease.
Limitations
Narrative review with no stated search strategy or quality appraisal; MOTS-c is covered as one of many microproteins and polymorphisms, so its specific evidence base is not separately assessed.
Study record
| Study model | Review |
|---|---|
| Substance studied | SeveralMore than one of these is central to the paper (common for reviews). |
| Species | Not reported |
| System studied | Published literature on sports genetics, mitochondrial DNA variants and mitochondrial microproteins |
| Population | Not reported |
| Design | Narrative review |
| Sample size as reported | Not reported |
| Control group | Not reported |
| Route (data field only) | Not reported |
| Endpoints measured | genetic polymorphisms and athletic performance; sports injury genetic markers; mitochondrial microprotein biology; age-related disease associations |
| Pathways measured | Not reported |
| Research areas | Exercise · Aging · Mitochondrial biology |
| Evidence tier | R — Review (context, not evidence) |
| Publication types | Journal Article, Review, Research Support, N.I.H., Extramural |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Peripheral
- Model applicability
- n/a
- Sample size
- n/a
- Controls
- n/a
- Outcome validity
- n/a
- Support for its own conclusion
- Moderate
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.