Study record
Mitochondrial-Encoded Peptide MOTS-c, Diabetes, and Aging-Related Diseases
Kong BS, Lee C, Cho YM · Diabetes Metab J · 2023
ReviewSeveralEvidence tier R
What this study reported
Reviewed published work on mitochondrial-encoded peptides, including MOTS-c, humanin, SHLP1-6 and SHMOOSE, with a focus on MOTS-c in type 1 and type 2 diabetes. Summarised reported associations between these peptides and cellular metabolism, insulin action and age-related disease across the cited studies.
Limitations
Narrative review with no stated search strategy or quality appraisal; covers several peptides at once so the MOTS-c-specific evidence is not systematically assembled.
Study record
| Study model | Review |
|---|---|
| Substance studied | SeveralMore than one of these is central to the paper (common for reviews). |
| Species | Not reported |
| System studied | Published literature on mitochondrial-encoded peptides in diabetes and age-related disease |
| Population | Not reported |
| Design | Narrative review |
| Sample size as reported | Not reported |
| Control group | Not reported |
| Route (data field only) | Not reported |
| Endpoints measured | cellular metabolism regulation; insulin action; type 1 and type 2 diabetes associations |
| Pathways measured | Insulin & glucose handling · AMPK signalling |
| Research areas | Metabolic · Aging |
| Evidence tier | R — Review (context, not evidence) |
| Publication types | Journal Article, Review, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- n/a
- Sample size
- n/a
- Controls
- n/a
- Outcome validity
- n/a
- Support for its own conclusion
- Moderate
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.