Study record
The protective effect of the mitochondrial-derived peptide MOTS-c on LPS-induced septic cardiomyopathy
Wu J, Xiao D, Yu K et al. · Acta Biochim Biophys Sin (Shanghai) · 2023
What this study reported
Reported that administered MOTS-c was associated with lower inflammatory cytokine mRNA in cardiomyocytes and lower circulating CK-MB and troponin T in a lipopolysaccharide-induced septic cardiomyopathy model, together with less mitochondrial dysfunction, less oxidative stress and less cardiomyocyte apoptosis. Reported higher AMPK, AKT and ERK signalling and lower JNK and STAT3 signalling, and that an AMPK inhibitor abolished these differences in the same model.
Limitations
The abstract does not state the species, group sizes, sex or randomisation; a single lipopolysaccharide-induced model with surrogate molecular endpoints and no survival or functional cardiac outcome reported.
Study record
| Study model | Animal study (in vivo) |
|---|---|
| Substance studied | MOTS-c administeredSynthetic MOTS-c was given to cells, animals or people. |
| Species | Not reported |
| System studied | Lipopolysaccharide-induced septic cardiomyopathy model with cardiomyocyte assays; species not stated in the abstract |
| Population | Not reported |
| Design | Controlled laboratory experiment with pharmacological pathway inhibition |
| Sample size as reported | Not reported |
| Control group | lipopolysaccharide-exposed model without MOTS-c, plus an AMPK-inhibitor (compound C) arm |
| Route (data field only) | Not reported |
| Endpoints measured | inflammatory cytokine mRNA (IL-1β, IL-4, IL-6, TNFα); circulating CK-MB and troponin T; mitochondrial function and oxidative stress; cardiomyocyte apoptosis; AMPK, AKT, ERK, JNK and STAT3 signalling |
| Pathways measured | AMPK signalling · AKT / mTOR / FOXO · MAPK signalling · Inflammation · Oxidative stress · Apoptosis |
| Research areas | Cardiovascular · Inflammation & immunity |
| Evidence tier | C — Animal in vivo |
| Publication types | Journal Article |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- Mammalian
- Sample size
- Not reported
- Controls
- Appropriate
- Outcome validity
- Surrogate
- Support for its own conclusion
- Moderate
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.