Study record
MOTS-c repairs myocardial damage by inhibiting the CCN1/ERK1/2/EGR1 pathway in diabetic rats
Wang M, Wang G, Pang X et al. · Front Nutr · 2022
What this study reported
Reported that in diabetic rats administered MOTS-c, myocardial mitochondrial damage was reduced and cardiac systolic and diastolic function preserved. Reported that transcriptomic analysis identified 47 altered disease-associated genes with enrichment for apoptosis, immunoregulation, angiogenesis and fatty acid metabolism, and that lower myocardial apoptosis was accompanied by downregulation of CCN1, reduced ERK1/2 activation and lower EGR1 expression.
Limitations
Composition and size of the comparison groups are not described in the abstract; single rat diabetes model with sex not reported; mechanism inferred from transcriptomic enrichment and expression changes without pathway blockade; endpoints are surrogate cardiac and molecular measures.
Study record
| Study model | Animal study (in vivo) |
|---|---|
| Substance studied | MOTS-c administeredSynthetic MOTS-c was given to cells, animals or people. |
| Species | rat |
| System studied | Diabetic rats given MOTS-c, with cardiac imaging, myocardial histology and myocardial transcriptomics |
| Population | Not reported |
| Design | Controlled animal experiment with transcriptomic analysis |
| Sample size as reported | Not reported |
| Control group | Not reported |
| Route (data field only) | Not reported |
| Endpoints measured | myocardial mitochondrial ultrastructure; cardiac systolic and diastolic function; myocardial transcriptome; myocardial apoptosis; CCN1, ERK1/2 and EGR1 expression |
| Pathways measured | Apoptosis · MAPK signalling · Lipid metabolism |
| Research areas | Cardiovascular · Metabolic |
| Evidence tier | C — Animal in vivo |
| Publication types | Journal Article |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- Mammalian
- Sample size
- Not reported
- Controls
- Limited
- Outcome validity
- Surrogate
- Support for its own conclusion
- Moderate
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.