Study record

MOTS-c Functionally Prevents Metabolic Disorders

Gao Y, Wei X, Wei P et al. · Metabolites · 2023

ReviewMOTS-c administeredEvidence tier R
PubMed 36677050doi:10.3390/metabo13010125Full text (PMC)Compare with another study

What this study reported

Reviewed reported genes and signalling pathways linked to MOTS-c in metabolic processes, describing the folate-methionine cycle and AICAR-AMPK route as the main proposed mechanism and summarising reported effects on insulin resistance, adiposity, muscle function, bone metabolism, immune regulation and aging across the cited studies.

Limitations

Narrative review with no stated search strategy or quality appraisal; the abstract frames preclinical findings in therapeutic terms that the underlying studies do not establish.

Study record

Annotated fields for this study
Study modelReview
Substance studiedMOTS-c administeredSynthetic MOTS-c was given to cells, animals or people.
SpeciesNot reported
System studiedPublished literature on MOTS-c-associated genes and pathways in metabolic processes
PopulationNot reported
DesignNarrative review
Sample size as reportedNot reported
Control groupNot reported
Route (data field only)Not reported
Endpoints measuredAICAR-AMPK signalling; insulin resistance and obesity measures; muscle and bone outcomes; GLUT4, STAT3 and IL-10 expression
Pathways measuredFolate cycle / purines / AICAR · AMPK signalling · Insulin & glucose handling
Research areasMetabolic
Evidence tierR — Review (context, not evidence)
Publication typesJournal Article, Review

Appraisal

Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.

Relevance to MOTS-c
Direct
Model applicability
n/a
Sample size
n/a
Controls
n/a
Outcome validity
n/a
Support for its own conclusion
Weak

Provenance

  • Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
  • Annotated from the published abstract.
  • Editorial review: approved (2026-11-11).
  • Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.