Study record
Mitochondria-derived peptide MOTS-c: effects and mechanisms related to stress, metabolism and aging
Wan W, Zhang L, Lin Y et al. · J Transl Med · 2023
What this study reported
Reviewed published work describing MOTS-c as a peptide encoded by the mitochondrial 12S rRNA gene that is reported to translocate to the nucleus under stress and to act largely through a folate-AICAR-AMPK route. Summarised reported links to energy metabolism, insulin resistance, inflammatory responses, exercise and aging-related processes across cell, animal and human studies.
Limitations
Narrative review with no stated search strategy, inclusion criteria or risk-of-bias assessment; the summarised evidence is mostly preclinical and is not weighted by study quality.
Study record
| Study model | Review |
|---|---|
| Substance studied | SeveralMore than one of these is central to the paper (common for reviews). |
| Species | Not reported |
| System studied | Published literature on MOTS-c in stress responses, energy metabolism and aging |
| Population | Not reported |
| Design | Narrative review |
| Sample size as reported | Not reported |
| Control group | Not reported |
| Route (data field only) | Not reported |
| Endpoints measured | retrograde mitochondrial-to-nuclear signalling; energy metabolism and insulin resistance; stress homeostasis; aging-related pathology |
| Pathways measured | Folate cycle / purines / AICAR · AMPK signalling · Nuclear translocation · NRF2 / antioxidant response |
| Research areas | Aging · Metabolic · Mitochondrial biology |
| Evidence tier | R — Review (context, not evidence) |
| Publication types | Journal Article, Review, Research Support, Non-U.S. Gov't |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- n/a
- Sample size
- n/a
- Controls
- n/a
- Outcome validity
- n/a
- Support for its own conclusion
- Moderate
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.