Study record
Evaluation of Coronary Flow Level with Mots-C in Patients with STEMI Undergoing Primary PCI
Çakmak T, Yaşar E, Çakmak E et al. · Arq Bras Cardiol · 2023
What this study reported
Measured serum MOTS-c at admission in adults with ST-elevation myocardial infarction undergoing primary PCI and in comparison patients. Found lower serum MOTS-c in the STEMI group than in the comparison group, and reported that lower admission MOTS-c discriminated the no-reflow phenomenon on ROC analysis and was associated with in-hospital major adverse cardiac events.
Limitations
Single-centre case-control design with fewer than 100 participants in total, a derived cut-off reported without external validation, and no adjustment described for infarct timing or comorbidity; the cross-sectional measurement cannot separate cause from consequence of infarction.
Study record
| Study model | Human observational |
|---|---|
| Substance studied | Endogenous MOTS-c measuredNaturally occurring MOTS-c was measured; nothing was given. |
| Species | human |
| System studied | Patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention and patients without significant coronary stenosis |
| Population | adults with ST-elevation myocardial infarction treated by primary PCI and comparison patients without coronary stenosis greater than 50% |
| Design | Case-control study with angiographic flow grading |
| Sample size as reported | 52 patients with STEMI and 42 patients without significant coronary stenosis |
| Control group | 42 patients without coronary stenosis greater than 50% |
| Route (data field only) | Not reported |
| Endpoints measured | serum MOTS-c; post-PCI TIMI flow grade / no-reflow; in-hospital major adverse cardiac events; ROC discrimination for no-reflow |
| Pathways measured | Not reported |
| Research areas | Cardiovascular |
| Evidence tier | B — Other human study |
| Publication types | Journal Article |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- Human
- Sample size
- Small
- Controls
- Appropriate
- Outcome validity
- Clinical outcome
- Support for its own conclusion
- Moderate
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.