Orally administered MOTS-c analogue ameliorates dextran sulfate sodium-induced colitis by inhibiting inflammation and apoptosis

What this study reported

Reported that intraperitoneally administered MOTS-c was associated with less body weight loss, less colon shortening and lower histological damage scores in mice with dextran sulfate sodium-induced colitis, together with lower pro-inflammatory cytokine expression, lower plasma myeloperoxidase and reduced phosphorylation of AMPKα1/2, ERK and JNK. Reported that orally administered MOTS-c produced no significant change in these mice, whereas a MOTS-c analogue linked to a cell-penetrating peptide showed a longer half-life in culture and was associated with reduced colitis severity when given orally.

Limitations

Single chemically induced colitis model in one mouse strain; sample sizes, sex and randomisation not reported in the abstract; the analogue comparison is not matched to an equivalent control peptide.