Study record
MOTS-c, the Most Recent Mitochondrial Derived Peptide in Human Aging and Age-Related Diseases
Mohtashami Z, Singh MK, Salimiaghdam N et al. · Int J Mol Sci · 2022
What this study reported
Reviewed MOTS-c as a 16-amino-acid peptide encoded in the 12S rRNA region that is reported to translocate to the nucleus under stress and to regulate metabolic genes. Summarised reports that plasma levels decline with age and that MOTS-c has been examined in relation to diabetes, cardiovascular disease, osteoporosis, postmenopausal obesity and Alzheimer disease, together with proposed mechanisms of action.
Limitations
Narrative review without a systematic search or quality appraisal; draws largely on preclinical reports and frames reversal of age-related decline as potential rather than demonstrated.
Study record
| Study model | Review |
|---|---|
| Substance studied | SeveralMore than one of these is central to the paper (common for reviews). |
| Species | Not reported |
| System studied | Narrative review of MOTS-c biology in human aging and age-related disorders |
| Population | Not reported |
| Design | Narrative review |
| Sample size as reported | Not reported |
| Control group | Not reported |
| Route (data field only) | Not reported |
| Endpoints measured | MOTS-c nuclear regulatory role; reported age-related decline in plasma MOTS-c; reported associations with age-related disorders |
| Pathways measured | Nuclear translocation |
| Research areas | Aging · Metabolic · Mitochondrial biology |
| Evidence tier | R — Review (context, not evidence) |
| Publication types | Journal Article, Review |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- n/a
- Sample size
- n/a
- Controls
- n/a
- Outcome validity
- n/a
- Support for its own conclusion
- Moderate
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.