Study record
Mitochondrial derived peptide MOTS-c prevents the development of heart failure under pressure overload conditions in mice
Zhong P, Peng J, Hu Y et al. · J Cell Mol Med · 2022
What this study reported
Reported that in mice subjected to transverse aortic constriction, administered MOTS-c attenuated cardiac dysfunction and remodelling, reduced inflammatory markers, raised antioxidant capacity and was accompanied by AMPK pathway activation in heart tissue. Reported that in cultured H9C2 cardiac cells, MOTS-c overexpression activated the AMPK pathway and reduced apoptosis after hydrogen peroxide exposure.
Limitations
Single pressure-overload model in one mouse strain with sex and group sizes not reported; cell work uses one cardiac cell line with overexpression rather than applied peptide; endpoints are surrogate measures of cardiac structure and signalling, with no survival or long-term outcome.
Study record
| Study model | Animal study (in vivo) |
|---|---|
| Substance studied | MOTS-c administeredSynthetic MOTS-c was given to cells, animals or people. |
| Species | mouse |
| System studied | Mice after transverse aortic constriction given MOTS-c by osmotic pump; cultured H9C2 cardiac cells overexpressing MOTS-c |
| Population | Not reported |
| Design | Controlled animal experiment with supporting cell culture experiments |
| Sample size as reported | Not reported |
| Control group | Transverse-aortic-constriction mice not given MOTS-c; untransfected H9C2 cells |
| Route (data field only) | subcutaneous |
| Endpoints measured | cardiac function by echocardiography; cardiac remodelling and histology; inflammatory markers; antioxidant capacity; AMPK pathway activation; cell death after H2O2 exposure |
| Pathways measured | AMPK signalling · Oxidative stress · Inflammation · Apoptosis |
| Research areas | Cardiovascular · Mitochondrial biology |
| Evidence tier | C — Animal in vivo |
| Publication types | Journal Article, Research Support, Non-U.S. Gov't |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- Mammalian
- Sample size
- Not reported
- Controls
- Appropriate
- Outcome validity
- Surrogate
- Support for its own conclusion
- Moderate
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.