Study record
MOTS-c as a predictor of coronary lesions and complexity in patients with stable coronary artery disease
Yaşar E, Çakmak T, Bayramoğlu A et al. · Eur Rev Med Pharmacol Sci · 2022
What this study reported
Measured circulating MOTS-c in patients with stable angina and reported lower levels in those with angiographically confirmed coronary artery disease than in those with normal coronary arteries. Reported that MOTS-c was an independent predictor of coronary artery disease in multiple regression analysis and described a receiver operating characteristic threshold with 80.3% sensitivity and 73.2% specificity in this sample.
Limitations
Cross-sectional single-centre design that cannot establish temporal order; measurement units for MOTS-c are not stated and the reported confidence interval is inconsistent with the reported area under the curve; diagnostic threshold derived and tested in the same sample without validation.
Study record
| Study model | Human observational |
|---|---|
| Substance studied | Endogenous MOTS-c measuredNaturally occurring MOTS-c was measured; nothing was given. |
| Species | human |
| System studied | Patients with stable angina undergoing coronary angiography, with and without angiographic coronary artery disease |
| Population | Adults with stable angina pectoris, with stable coronary artery disease or normal coronary arteries |
| Design | Case-control study with angiographic severity scoring |
| Sample size as reported | 184 patients (92 with coronary artery disease, 92 with normal coronary arteries) |
| Control group | 92 consecutive patients with normal coronary arteries |
| Route (data field only) | Not reported |
| Endpoints measured | circulating MOTS-c levels; presence of coronary artery disease; SYNTAX score |
| Pathways measured | Not reported |
| Research areas | Cardiovascular |
| Evidence tier | B — Other human study |
| Publication types | Journal Article |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- Human
- Sample size
- Small
- Controls
- Appropriate
- Outcome validity
- Exploratory
- Support for its own conclusion
- Weak
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.