Study record

Comparison of Serum Mitochondrial Open Reading Frame of the 12S rRNA-c (MOTS-c) Levels in Patients With Multiple Sclerosis and Healthy Controls

Tekin S, Bir LS, Avci E et al. · Cureus · 2022

Human obs.Endogenous MOTS-c measuredEvidence tier B
PubMed 35989823doi:10.7759/cureus.26981Full text (PMC)Compare with another study

What this study reported

Measured serum MOTS-c in adults with relapsing-remitting multiple sclerosis and healthy controls and reported significantly lower MOTS-c and higher fasting blood glucose and HOMA-IR values in the patient group. Reported an area under the receiver operating characteristic curve of 0.782 for MOTS-c in separating patients from controls in this sample.

Limitations

Small single-centre case-control sample; cross-sectional measurement cannot establish temporal order; discriminative performance assessed in the same sample without external validation; disease duration and treatment status not described in the abstract.

Study record

Annotated fields for this study
Study modelHuman observational
Substance studiedEndogenous MOTS-c measuredNaturally occurring MOTS-c was measured; nothing was given.
Specieshuman
System studiedPatients with relapsing-remitting multiple sclerosis and healthy controls; serum MOTS-c and metabolic panel
PopulationAdults with relapsing-remitting multiple sclerosis and healthy controls
DesignCase-control study
Sample size as reported84 participants (43 with relapsing-remitting multiple sclerosis, 41 healthy controls)
Control group41 healthy controls
Route (data field only)Not reported
Endpoints measuredserum MOTS-c; fasting blood glucose; insulin and HOMA-IR; lipid panel; body mass index
Pathways measuredInsulin & glucose handling
Research areasNervous system · Metabolic · Inflammation & immunity
Evidence tierB — Other human study
Publication typesJournal Article

Appraisal

Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.

Relevance to MOTS-c
Direct
Model applicability
Human
Sample size
Small
Controls
Appropriate
Outcome validity
Exploratory
Support for its own conclusion
Weak

Provenance

  • Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
  • Annotated from the published abstract.
  • Editorial review: approved (2026-11-11).
  • Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.