Study record
Exercise and Metabolic Health: The Emerging Roles of Novel Exerkines
Türkel İ, Özerkliğ B, Atakan MM et al. · Curr Protein Pept Sci · 2022
ReviewEndogenous MOTS-c measuredEvidence tier R
What this study reported
Reviewed exercise-induced molecules, listing MOTS-c alongside BDNF, miR-1, 12,13-diHOME, irisin, SPX, osteocalcin, GDF15 and FGF21, and summarised reported relationships with obesity, insulin resistance and type 2 diabetes. MOTS-c is mentioned as one item in a broader exerkine summary rather than examined in detail.
Limitations
Broad narrative review with no systematic search; MOTS-c receives only brief coverage among many molecules, and no primary data are presented.
Study record
| Study model | Review |
|---|---|
| Substance studied | Endogenous MOTS-c measuredNaturally occurring MOTS-c was measured; nothing was given. |
| Species | Not reported |
| System studied | Narrative review of exercise-induced signalling molecules (exerkines) from muscle, adipose tissue, bone and liver |
| Population | Not reported |
| Design | Narrative review |
| Sample size as reported | Not reported |
| Control group | Not reported |
| Route (data field only) | Not reported |
| Endpoints measured | reported exerkine effects on obesity; insulin resistance; type 2 diabetes |
| Pathways measured | Insulin & glucose handling |
| Research areas | Exercise · Metabolic |
| Evidence tier | R — Review (context, not evidence) |
| Publication types | Journal Article |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Peripheral
- Model applicability
- n/a
- Sample size
- n/a
- Controls
- n/a
- Outcome validity
- n/a
- Support for its own conclusion
- Weak
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.