Study record
Exercise, Mitohormesis, and Mitochondrial ORF of the 12S rRNA Type-C (MOTS-c)
Yoon TK, Lee CH, Kwon O et al. · Diabetes Metab J · 2022
What this study reported
Reviewed mitohormetic responses to exercise, including reactive oxygen species production, the mitochondrial unfolded protein response and release of mitochondria-derived peptides. Summarised reports that MOTS-c expression rises in skeletal muscle, circulation and hypothalamus after exercise, and that in animal reports administered MOTS-c increased exercise performance and stimulated thermogenesis in subcutaneous white adipose tissue.
Limitations
Narrative review without a systematic search; summarises largely rodent findings and does not separate human from animal evidence in the abstract.
Study record
| Study model | Review |
|---|---|
| Substance studied | SeveralMore than one of these is central to the paper (common for reviews). |
| Species | Not reported |
| System studied | Narrative review of exercise-related mitohormesis with a focus on MOTS-c |
| Population | Not reported |
| Design | Narrative review |
| Sample size as reported | Not reported |
| Control group | Not reported |
| Route (data field only) | Not reported |
| Endpoints measured | MOTS-c expression after exercise; exercise performance; adipose thermogenesis; energy expenditure |
| Pathways measured | Thermogenesis / brown fat · Oxidative stress |
| Research areas | Exercise · Metabolic · Mitochondrial biology |
| Evidence tier | R — Review (context, not evidence) |
| Publication types | Journal Article, Review, Research Support, Non-U.S. Gov't |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- n/a
- Sample size
- n/a
- Controls
- n/a
- Outcome validity
- n/a
- Support for its own conclusion
- Moderate
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.