Study record
MOTS-c and Exercise Restore Cardiac Function by Activating of NRG1-ErbB Signaling in Diabetic Rats
Li S, Wang M, Ma J et al. · Front Endocrinol (Lausanne) · 2022
What this study reported
Reported that both aerobic exercise and administered MOTS-c reduced abnormalities in cardiac structure and function in a rat model of type 2 diabetes. Transcriptomic analysis showed overlapping effects on inflammation, myocardial apoptosis and angiogenesis, with NRG1-ErbB4 signalling identified as a shared component.
Limitations
Chemically and diet-induced diabetes model in a single rat strain, group sizes and sex not reported in the abstract, and pathway involvement inferred from transcriptomic enrichment rather than from blocking experiments.
Study record
| Study model | Animal study (in vivo) |
|---|---|
| Substance studied | MOTS-c administeredSynthetic MOTS-c was given to cells, animals or people. |
| Species | rat |
| System studied | Rat model of type 2 diabetes induced by a high-fat, high-sugar diet with low-dose streptozotocin, given MOTS-c or aerobic exercise |
| Population | Not reported |
| Design | Controlled animal experiment |
| Sample size as reported | Not reported |
| Control group | untreated diabetic rats |
| Route (data field only) | Not reported |
| Endpoints measured | cardiac structure and function; cardiac transcriptome; NRG1-ErbB4 signalling; inflammation; myocardial apoptosis; angiogenesis markers |
| Pathways measured | Inflammation · Apoptosis · Insulin & glucose handling · Other |
| Research areas | Cardiovascular · Metabolic · Exercise |
| Evidence tier | C — Animal in vivo |
| Publication types | Journal Article |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- Mammalian
- Sample size
- Not reported
- Controls
- Appropriate
- Outcome validity
- Surrogate
- Support for its own conclusion
- Moderate
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.