Study record

Mitochondrial-Derived Peptides in Diabetes and Its Complications

Wu Y, Sun L, Zhuang Z et al. · Front Endocrinol (Lausanne) · 2021

ReviewRelated mitochondrial peptideEvidence tier R
PubMed 35185787doi:10.3389/fendo.2021.808120Full text (PMC)Compare with another study

What this study reported

Reviewed humanin, MOTS-c and SHLP1-6 in diabetes and its complications, summarising reported effects on insulin resistance, inflammatory responses and apoptosis. Complications discussed include stroke and myocardial infarction.

Limitations

Narrative review without systematic search; MOTS-c is one of several peptides covered and the evidence summarised is mainly preclinical.

Study record

Annotated fields for this study
Study modelReview
Substance studiedRelated mitochondrial peptideThe paper is mainly about another mitochondrial-derived peptide, such as humanin.
SpeciesNot reported
System studiedNarrative review of mitochondrial-derived peptides in diabetes and its complications
PopulationNot reported
DesignNarrative review
Sample size as reportedNot reported
Control groupNot reported
Route (data field only)Not reported
Endpoints measuredinsulin resistance; inflammatory response; apoptosis
Pathways measuredInsulin & glucose handling · Inflammation · Apoptosis
Research areasMetabolic · Cardiovascular
Evidence tierR — Review (context, not evidence)
Publication typesJournal Article, Research Support, Non-U.S. Gov't, Review

Appraisal

Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.

Relevance to MOTS-c
Indirect
Model applicability
n/a
Sample size
n/a
Controls
n/a
Outcome validity
n/a
Support for its own conclusion
Moderate

Provenance

  • Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
  • Annotated from the published abstract.
  • Editorial review: approved (2026-11-11).
  • Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.