Study record
Mitochondrial-derived peptides: New markers for cardiometabolic dysfunction
Rochette L, Rigal E, Dogon G et al. · Arch Cardiovasc Dis · 2022
ReviewEndogenous MOTS-c measuredEvidence tier R
What this study reported
Reviewed humanin, MOTS-c and small humanin-like peptides as circulating markers that may reflect mitochondrial function in cardiometabolic disease. Described their reported antioxidant, anti-inflammatory and anti-apoptotic actions and discussed their proposed use as biomarkers.
Limitations
Narrative review without systematic search; biomarker claims rest on small cross-sectional human studies and assay methods differ between them.
Study record
| Study model | Review |
|---|---|
| Substance studied | Endogenous MOTS-c measuredNaturally occurring MOTS-c was measured; nothing was given. |
| Species | Not reported |
| System studied | Narrative review of circulating mitochondrial-derived peptides as cardiometabolic biomarkers |
| Population | Not reported |
| Design | Narrative review |
| Sample size as reported | Not reported |
| Control group | Not reported |
| Route (data field only) | Not reported |
| Endpoints measured | circulating MDP concentrations; oxidative stress; inflammation; apoptosis |
| Pathways measured | Oxidative stress · Inflammation · Apoptosis · Nuclear translocation |
| Research areas | Cardiovascular · Metabolic |
| Evidence tier | R — Review (context, not evidence) |
| Publication types | Journal Article, Review |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Indirect
- Model applicability
- n/a
- Sample size
- n/a
- Controls
- n/a
- Outcome validity
- n/a
- Support for its own conclusion
- Moderate
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.