Study record
[Effects of exercise intervention on mitochondrial-derived peptide MOTS-c in the germ cells of obese men]
Li YR, Kang MS, Yi XJ · Zhonghua Nan Ke Xue · 2021
ReviewEndogenous MOTS-c measuredEvidence tier R
What this study reported
Reviewed MOTS-c as a mitochondrial-derived peptide linked to glucose metabolism and adiposity, noting reports of lower circulating MOTS-c in obese men and sex-related differences. Discussed how exercise intervention might relate to MOTS-c in the germ cells of obese men.
Limitations
Short narrative review in a single-topic journal with no systematic search, and the proposed link between exercise, MOTS-c and germ cells is largely speculative.
Study record
| Study model | Review |
|---|---|
| Substance studied | Endogenous MOTS-c measuredNaturally occurring MOTS-c was measured; nothing was given. |
| Species | Not reported |
| System studied | Narrative review of exercise, MOTS-c and germ cells in obese men |
| Population | Not reported |
| Design | Narrative review |
| Sample size as reported | Not reported |
| Control group | Not reported |
| Route (data field only) | Not reported |
| Endpoints measured | circulating MOTS-c; glucose metabolism; adipose tissue; male reproductive function |
| Pathways measured | Insulin & glucose handling · Lipid metabolism |
| Research areas | Reproductive · Exercise · Metabolic |
| Evidence tier | R — Review (context, not evidence) |
| Publication types | Journal Article, Review |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Indirect
- Model applicability
- n/a
- Sample size
- n/a
- Controls
- n/a
- Outcome validity
- n/a
- Support for its own conclusion
- Weak
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.