Study record
Cardio-protective role of Humanin in myocardial ischemia-reperfusion
Gong Z, Goetzman E, Muzumdar RH · Biochim Biophys Acta Gen Subj · 2022
ReviewRelated mitochondrial peptideEvidence tier R
What this study reported
Reviewed humanin and its reported role in cardioprotection after myocardial ischaemia-reperfusion injury, naming MOTS-c only as another member of the mitochondria-derived peptide family. No MOTS-c-specific data are summarised.
Limitations
Minireview focused on humanin with MOTS-c mentioned only in passing, so it contributes no MOTS-c-specific evidence.
Study record
| Study model | Review |
|---|---|
| Substance studied | Related mitochondrial peptideThe paper is mainly about another mitochondrial-derived peptide, such as humanin. |
| Species | Not reported |
| System studied | Narrative minireview of humanin in myocardial ischaemia-reperfusion injury |
| Population | Not reported |
| Design | Narrative review |
| Sample size as reported | Not reported |
| Control group | Not reported |
| Route (data field only) | Not reported |
| Endpoints measured | apoptosis; oxidative stress; autophagy; ER stress |
| Pathways measured | Apoptosis · Oxidative stress · Autophagy / mitophagy |
| Research areas | Cardiovascular |
| Evidence tier | R — Review (context, not evidence) |
| Publication types | Journal Article, Review |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Peripheral
- Model applicability
- n/a
- Sample size
- n/a
- Controls
- n/a
- Outcome validity
- n/a
- Support for its own conclusion
- Weak
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.