Study record
The mitochondrial-derived peptide MOTS-c relieves hyperglycemia and insulin resistance in gestational diabetes mellitus
Yin Y, Pan Y, He J et al. · Pharmacol Res · 2022
What this study reported
Reported that administered MOTS-c lowered hyperglycaemia and improved insulin sensitivity and glucose tolerance in a mouse model of gestational diabetes, with lower birth weight and fewer offspring deaths than in untreated model mice. In vitro, MOTS-c increased glucose uptake and was associated with less streptozotocin-related injury to pancreatic beta-cells.
Limitations
Chemically and diet-induced model in a single mouse strain that only partly reproduces human gestational diabetes; group sizes and blinding are not reported, and reproductive outcomes are short-term.
Study record
| Study model | Animal study (in vivo) |
|---|---|
| Substance studied | MOTS-c administeredSynthetic MOTS-c was given to cells, animals or people. |
| Species | mouse |
| System studied | C57BL/6 mouse model of gestational diabetes induced by high-fat diet and streptozotocin, with skeletal muscle cells and pancreatic beta-cells in vitro |
| Population | Not reported |
| Design | Controlled animal experiment with cell culture experiments |
| Sample size as reported | Not reported |
| Control group | untreated gestational diabetes model mice |
| Route (data field only) | Not reported |
| Endpoints measured | blood glucose; insulin levels; glucose and insulin tolerance; birth weight; offspring survival; glucose uptake; beta-cell injury |
| Pathways measured | Insulin & glucose handling · Apoptosis |
| Research areas | Pregnancy · Metabolic |
| Evidence tier | C — Animal in vivo |
| Publication types | Journal Article, Research Support, Non-U.S. Gov't |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- Mammalian
- Sample size
- Not reported
- Controls
- Appropriate
- Outcome validity
- Surrogate
- Support for its own conclusion
- Moderate
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.