Study record
The emerging role of mitochondrial derived peptide humanin in the testis
Lue Y, Swerdloff R, Jia Y et al. · Biochim Biophys Acta Gen Subj · 2021
ReviewRelated mitochondrial peptideEvidence tier R
What this study reported
Reviewed humanin as a regulator of germ cell apoptosis and testicular stress responses in rodents, noting that MOTS-c and SHLP-2 are also present in testes. MOTS-c is mentioned only as a co-occurring peptide, with no MOTS-c-specific data summarised.
Limitations
Narrative review centred on humanin and its analogue; MOTS-c receives only passing mention and the underlying evidence is rodent-based.
Study record
| Study model | Review |
|---|---|
| Substance studied | Related mitochondrial peptideThe paper is mainly about another mitochondrial-derived peptide, such as humanin. |
| Species | Not reported |
| System studied | Narrative review of humanin in the testis, noting MOTS-c and SHLP-2 presence |
| Population | Not reported |
| Design | Narrative review |
| Sample size as reported | Not reported |
| Control group | Not reported |
| Route (data field only) | Not reported |
| Endpoints measured | germ cell apoptosis; testicular stress responses; cytokine networks |
| Pathways measured | Apoptosis · Inflammation |
| Research areas | Reproductive |
| Evidence tier | R — Review (context, not evidence) |
| Publication types | Journal Article, Review |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Peripheral
- Model applicability
- n/a
- Sample size
- n/a
- Controls
- n/a
- Outcome validity
- n/a
- Support for its own conclusion
- Weak
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.