Study record
Effect of aerobic and resistance exercise on the mitochondrial peptide MOTS-c in Hispanic and Non-Hispanic White breast cancer survivors
Dieli-Conwright CM, Sami N, Norris MK et al. · Sci Rep · 2021
What this study reported
Measured fasting plasma MOTS-c in breast cancer survivors over a 16-week aerobic and resistance exercise intervention and found higher post-intervention levels than at baseline and than usual care among non-Hispanic White survivors, but not among Hispanic survivors. Post-intervention MOTS-c levels in non-Hispanic White survivors were associated with lower fat mass, body weight, HOMA-IR and C-reactive protein and higher lean mass.
Limitations
Secondary analysis of a trial not designed for this outcome, small ethnic subgroups with baseline differences in age, adiposity and cancer stage, women only, and MOTS-c measured with an in-house ELISA.
Study record
| Study model | Human observational |
|---|---|
| Substance studied | Endogenous MOTS-c measuredNaturally occurring MOTS-c was measured; nothing was given. |
| Species | human |
| System studied | Hispanic and non-Hispanic White breast cancer survivors randomised to an aerobic and resistance exercise programme or standard care |
| Population | women treated for stage I-III breast cancer, Hispanic and non-Hispanic White |
| Design | Secondary analysis of a randomised exercise intervention; MOTS-c measured |
| Sample size as reported | 49 participants (25 Hispanic, 24 non-Hispanic White) |
| Control group | standard care (usual care) group |
| Route (data field only) | Not reported |
| Endpoints measured | plasma MOTS-c; fat mass; lean mass; body weight; HOMA-IR; C-reactive protein |
| Pathways measured | Insulin & glucose handling · Inflammation |
| Research areas | Exercise · Cancer · Metabolic |
| Evidence tier | B — Other human study |
| Publication types | Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- Human
- Sample size
- Small
- Controls
- Appropriate
- Outcome validity
- Validated biomarker
- Support for its own conclusion
- Moderate
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.