Study record
Peripheral Administration of a Cell-Penetrating MOTS-c Analogue Enhances Memory and Attenuates Aβ1-42- or LPS-Induced Memory Impairment through Inhibiting Neuroinflammation
Jiang J, Chang X, Nie Y et al. · ACS Chem Neurosci · 2021
What this study reported
Reported that centrally administered MOTS-c increased object and location recognition memory formation and consolidation in animals and reduced memory deficits induced by amyloid-beta or LPS, with the effect blocked by an AMPK inhibitor. MOTS-c given peripherally did not cross the blood-brain barrier, whereas a cell-penetrating MOTS-c analogue given intranasally or intravenously reached the brain and was associated with memory performance changes.
Limitations
Species and group sizes are not stated in the abstract, behavioural outcomes are short-term recognition tasks in acutely induced deficit models, and the analogue results rest on imaging-based biodistribution without blinding details.
Study record
| Study model | Animal study (in vivo) |
|---|---|
| Substance studied | SeveralMore than one of these is central to the paper (common for reviews). |
| Species | Not reported |
| System studied | Rodent memory models with central MOTS-c and with a cell-penetrating MOTS-c analogue; species not specified in the abstract |
| Population | Not reported |
| Design | Controlled animal experiment |
| Sample size as reported | Not reported |
| Control group | vehicle-treated animals and AMPK-inhibitor comparison groups |
| Route (data field only) | other |
| Endpoints measured | object and location recognition memory; AMPK phosphorylation; astrocyte and microglial activation; proinflammatory cytokines; brain biodistribution |
| Pathways measured | AMPK signalling · Inflammation |
| Research areas | Nervous system · Inflammation & immunity |
| Evidence tier | C — Animal in vivo |
| Publication types | Journal Article, Research Support, Non-U.S. Gov't |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- Mammalian
- Sample size
- Not reported
- Controls
- Appropriate
- Outcome validity
- Surrogate
- Support for its own conclusion
- Moderate
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.