Study record
The mitochondrial-derived peptide MOTS-c promotes homeostasis in aged human placenta-derived mesenchymal stem cells in vitro
Yu WD, Kim YJ, Cho MJ et al. · Mitochondrion · 2021
CellsMOTS-c administeredEvidence tier D
What this study reported
Reported that MOTS-c applied to aged human placenta-derived mesenchymal stem cells improved cell morphology, increased AMPK activation and reduced mTORC1 activity. Oxygen consumption, reactive oxygen species production and lipid synthesis were lower in treated aged cells, which resembled young cells more closely than untreated aged cells did.
Limitations
Single donor-derived cell type studied in culture with no in vivo validation; ageing is modelled by culture passage, and the treated-cell comparison with young cells is descriptive.
Study record
| Study model | Cell study (in vitro) |
|---|---|
| Substance studied | MOTS-c administeredSynthetic MOTS-c was given to cells, animals or people. |
| Species | human |
| System studied | Aged and young human placenta-derived mesenchymal stem cells in culture |
| Population | Not reported |
| Design | Cell culture experiments |
| Sample size as reported | Not reported |
| Control group | untreated old and young human placenta-derived mesenchymal stem cells |
| Route (data field only) | in-culture |
| Endpoints measured | cell morphology; AMPK activation; mTORC1 activity; oxygen consumption; reactive oxygen species; lipid synthesis |
| Pathways measured | AMPK signalling · AKT / mTOR / FOXO · Oxidative stress · Lipid metabolism |
| Research areas | Aging · Mitochondrial biology |
| Evidence tier | D — Cell, tissue or analytical |
| Publication types | Journal Article, Research Support, Non-U.S. Gov't |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- Cellular
- Sample size
- Not reported
- Controls
- Appropriate
- Outcome validity
- Surrogate
- Support for its own conclusion
- Moderate
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.