Study record
Mitohormesis in Hypothalamic POMC Neurons Mediates Regular Exercise-Induced High-Turnover Metabolism
Kang GM, Min SH, Lee CH et al. · Cell Metab · 2021
What this study reported
Reported that mild mitoribosomal stress in mouse POMC neurons raised hypothalamic MOTS-c and beta-endorphin expression and was associated with higher-turnover metabolism and resistance to obesity. Central administration of MOTS-c in mice reproduced the adipose thermogenic and unfolded-protein-response phenotype, and moderate running exercise was associated with higher hypothalamic MOTS-c expression.
Limitations
Single mouse strain and male mice only, with MOTS-c identified as a candidate mediator by phenocopying rather than by blocking its action; central delivery does not reflect endogenous hypothalamic exposure.
Study record
| Study model | Animal study (in vivo) |
|---|---|
| Substance studied | SeveralMore than one of these is central to the paper (common for reviews). |
| Species | mouse |
| System studied | POMC neuron-specific Crif1-deficient mice, exercising wild-type mice given central MOTS-c, and hypothalamic cell lines |
| Population | Not reported |
| Design | Controlled animal experiment with transgenic models |
| Sample size as reported | Not reported |
| Control group | wild-type and vehicle-infused mice |
| Route (data field only) | intracerebroventricular |
| Endpoints measured | body weight and adiposity; thermogenesis; adipose mitochondrial unfolded protein response; hypothalamic MOTS-c expression |
| Pathways measured | Thermogenesis / brown fat · Other |
| Research areas | Metabolic · Nervous system · Exercise · Mitochondrial biology |
| Evidence tier | C — Animal in vivo |
| Publication types | Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Indirect
- Model applicability
- Mammalian
- Sample size
- Not reported
- Controls
- Appropriate
- Outcome validity
- Surrogate
- Support for its own conclusion
- Moderate
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.