Study record
Relationship between the mitochondria-derived peptide MOTS-c and insulin resistance in obstructive sleep apnea
Baylan FA, Yarar E · Sleep Breath · 2021
Human obs.Endogenous MOTS-c measuredEvidence tier B
What this study reported
Found lower serum MOTS-c in adults with obstructive sleep apnoea than in healthy controls, with levels decreasing as apnoea severity increased. Reported negative correlations between serum MOTS-c and both apnoea-hypopnoea index and BMI, and an independent association with apnoea-hypopnoea index in regression analysis.
Limitations
Cross-sectional single-centre design with a small control group, a male-predominant sample, and no adjustment described for confounders beyond those entered into the regression; causality cannot be inferred.
Study record
| Study model | Human observational |
|---|---|
| Substance studied | Endogenous MOTS-c measuredNaturally occurring MOTS-c was measured; nothing was given. |
| Species | human |
| System studied | Adults with obstructive sleep apnoea graded by severity and healthy controls |
| Population | adults with obstructive sleep apnoea (mild, moderate, severe) and healthy controls |
| Design | Case-control study |
| Sample size as reported | 90 participants (70 with OSA, 20 controls) |
| Control group | 20 healthy controls with AHI 5 or below |
| Route (data field only) | Not reported |
| Endpoints measured | serum MOTS-c; apnoea-hypopnoea index; HOMA-IR; BMI; lipid and glucose profile |
| Pathways measured | Insulin & glucose handling |
| Research areas | Metabolic · Lung |
| Evidence tier | B — Other human study |
| Publication types | Journal Article |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- Human
- Sample size
- Small
- Controls
- Limited
- Outcome validity
- Validated biomarker
- Support for its own conclusion
- Moderate
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.