Study record

Mitochondrial-derived peptides in aging and age-related diseases

Kim SJ, Miller B, Kumagai H et al. · Geroscience · 2021

ReviewSeveralEvidence tier R
PubMed 32910336doi:10.1007/s11357-020-00262-5Full text (PMC)Compare with another study

What this study reported

Reviewed evidence that levels of mitochondrial-derived peptides, including MOTS-c, decline with age and relate to senescence, chronic inflammation and cognitive decline. Also summarised coding-region variants in MOTS-c and humanin reported to associate with age-related disease.

Limitations

Narrative review without systematic search; much of the cited MOTS-c evidence is preclinical or based on cross-sectional associations.

Study record

Annotated fields for this study
Study modelReview
Substance studiedSeveralMore than one of these is central to the paper (common for reviews).
SpeciesNot reported
System studiedNarrative review of humanin and MOTS-c in ageing and age-related disease
PopulationNot reported
DesignNarrative review
Sample size as reportedNot reported
Control groupNot reported
Route (data field only)Not reported
Endpoints measuredcellular senescence; chronic inflammation; cognitive decline; MDP genetic variation
Pathways measuredInflammation · Other
Research areasAging · Mitochondrial biology · Nervous system
Evidence tierR — Review (context, not evidence)
Publication typesJournal Article, Research Support, Non-U.S. Gov't, Review

Appraisal

Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.

Relevance to MOTS-c
Direct
Model applicability
n/a
Sample size
n/a
Controls
n/a
Outcome validity
n/a
Support for its own conclusion
Moderate

Provenance

  • Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
  • Annotated from the published abstract.
  • Editorial review: approved (2026-11-11).
  • Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.