Study record
Role of humanin, a mitochondrial-derived peptide, in cardiovascular disorders
Rochette L, Meloux A, Zeller M et al. · Arch Cardiovasc Dis · 2020
ReviewRelated mitochondrial peptideEvidence tier R
What this study reported
Reviewed humanin as a regulator of oxidative stress and metabolism in cardiovascular disorders, naming MOTS-c as a member of the same peptide class. MOTS-c itself is not the focus and no MOTS-c-specific data are summarised.
Limitations
Narrative review centred on humanin; MOTS-c appears only as part of the peptide class description, so it provides no MOTS-c-specific evidence.
Study record
| Study model | Review |
|---|---|
| Substance studied | Related mitochondrial peptideThe paper is mainly about another mitochondrial-derived peptide, such as humanin. |
| Species | Not reported |
| System studied | Narrative review of humanin in cardiovascular disorders, with other mitochondrial-derived peptides noted |
| Population | Not reported |
| Design | Narrative review |
| Sample size as reported | Not reported |
| Control group | Not reported |
| Route (data field only) | Not reported |
| Endpoints measured | oxidative stress; mitochondrial complex 1 activity; metabolic regulation |
| Pathways measured | Oxidative stress · Nuclear translocation |
| Research areas | Cardiovascular · Metabolic |
| Evidence tier | R — Review (context, not evidence) |
| Publication types | Journal Article, Review |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Peripheral
- Model applicability
- n/a
- Sample size
- n/a
- Controls
- n/a
- Outcome validity
- n/a
- Support for its own conclusion
- Weak
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.