Study record
Peptides derived from small mitochondrial open reading frames: Genomic, biological, and therapeutic implications
Miller B, Kim SJ, Kumagai H et al. · Exp Cell Res · 2020
ReviewSeveralEvidence tier R
What this study reported
Reviewed the eight characterised mitochondrial-derived peptides, including MOTS-c, and their reported effects on cell metabolism across several disease settings. Noted that a polymorphism in the MOTS-c coding region has been associated with diabetes in human genetic studies.
Limitations
Narrative review without systematic search; MOTS-c is one of several peptides covered and the genetic associations summarised come from a small number of cohorts.
Study record
| Study model | Review |
|---|---|
| Substance studied | SeveralMore than one of these is central to the paper (common for reviews). |
| Species | Not reported |
| System studied | Narrative review of peptides encoded by small mitochondrial open reading frames |
| Population | Not reported |
| Design | Narrative review |
| Sample size as reported | Not reported |
| Control group | Not reported |
| Route (data field only) | Not reported |
| Endpoints measured | cell metabolism; disease association; genetic variation in MDP coding regions |
| Pathways measured | Other |
| Research areas | Metabolic · Aging · Mitochondrial biology |
| Evidence tier | R — Review (context, not evidence) |
| Publication types | Journal Article, Research Support, N.I.H., Extramural, Review |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Indirect
- Model applicability
- n/a
- Sample size
- n/a
- Controls
- n/a
- Outcome validity
- n/a
- Support for its own conclusion
- Moderate
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.