Study record

Effects of Mitochondrial-Derived Peptides (MDPs) on Mitochondrial and Cellular Health in AMD

Nashine S, Kenney MC · Cells · 2020

ReviewRelated mitochondrial peptideEvidence tier R
PubMed 32365540doi:10.3390/cells9051102Full text (PMC)Compare with another study

What this study reported

Reviewed reported effects of mitochondrial-derived peptides, including MOTS-c, on cellular and mitochondrial health in the context of age-related macular degeneration. Summarised cytoprotective roles described in earlier cell and animal work rather than presenting new data.

Limitations

Narrative review with no systematic search; MOTS-c is discussed alongside other mitochondrial-derived peptides and the underlying evidence is largely preclinical.

Study record

Annotated fields for this study
Study modelReview
Substance studiedRelated mitochondrial peptideThe paper is mainly about another mitochondrial-derived peptide, such as humanin.
SpeciesNot reported
System studiedNarrative review of mitochondrial-derived peptides in age-related macular degeneration
PopulationNot reported
DesignNarrative review
Sample size as reportedNot reported
Control groupNot reported
Route (data field only)Not reported
Endpoints measuredmitochondrial health; cell death; cytoprotection
Pathways measuredOxidative stress · Other
Research areasAging · Mitochondrial biology
Evidence tierR — Review (context, not evidence)
Publication typesJournal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review

Appraisal

Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.

Relevance to MOTS-c
Indirect
Model applicability
n/a
Sample size
n/a
Controls
n/a
Outcome validity
n/a
Support for its own conclusion
Moderate

Provenance

  • Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
  • Annotated from the published abstract.
  • Editorial review: approved (2026-11-11).
  • Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.