Study record
Role of the mitochondrial stress response in human cancer progression
Wang SF, Chen S, Tseng LM et al. · Exp Biol Med (Maywood) · 2020
ReviewRelated mitochondrial peptideEvidence tier R
What this study reported
Reviewed mitochondrial stress responses in cancer and listed MOTS-c among mitochondrion-derived molecules (with humanin, ROS, oncometabolites and exported mtDNA) described as retrograde signals. MOTS-c is mentioned only as one member of that set, with no MOTS-c-specific data presented.
Limitations
Narrative review without systematic search; MOTS-c is named only within a list of mitochondrial signals and no primary MOTS-c data are summarised.
Study record
| Study model | Review |
|---|---|
| Substance studied | Related mitochondrial peptideThe paper is mainly about another mitochondrial-derived peptide, such as humanin. |
| Species | Not reported |
| System studied | Narrative review of mitochondrial stress responses and mitochondrion-derived molecules in cancer |
| Population | Not reported |
| Design | Narrative review |
| Sample size as reported | Not reported |
| Control group | Not reported |
| Route (data field only) | Not reported |
| Endpoints measured | mitochondrial retrograde signalling; mitochondrial unfolded protein response; cancer progression |
| Pathways measured | Other |
| Research areas | Cancer · Mitochondrial biology |
| Evidence tier | R — Review (context, not evidence) |
| Publication types | Journal Article, Research Support, Non-U.S. Gov't, Review |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Peripheral
- Model applicability
- n/a
- Sample size
- n/a
- Controls
- n/a
- Outcome validity
- n/a
- Support for its own conclusion
- Weak
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.