Study record
Protective effect of MOTS-c on acute lung injury induced by lipopolysaccharide in mice
Xinqiang Y, Quan C, Yuanyuan J et al. · Int Immunopharmacol · 2020
AnimalMOTS-c administeredEvidence tier C
What this study reported
In mice given MOTS-c before LPS instillation, the authors reported less body weight loss, pulmonary oedema and lung neutrophil infiltration, lower TNF-α, IL-1β and IL-6, and higher IL-10 and SOD. MOTS-c was associated with increased p-AMPKα and SIRT1 and reduced ERK, JNK, p38, p65 and STAT3 activation in lung tissue.
Limitations
Males only; pretreatment design before injury; group sizes not reported in the abstract; mechanism inferred without pathway-blocking experiments.
Study record
| Study model | Animal study (in vivo) |
|---|---|
| Substance studied | MOTS-c administeredSynthetic MOTS-c was given to cells, animals or people. |
| Species | mouse |
| System studied | Male BALB/c mice with intratracheal LPS-induced acute lung injury |
| Population | Not reported |
| Design | Controlled animal experiment |
| Sample size as reported | Not reported |
| Control group | LPS-challenged mice not given MOTS-c (implied) |
| Route (data field only) | intraperitoneal |
| Endpoints measured | body weight loss and pulmonary oedema; lung neutrophil infiltration; TNF-α, IL-1β, IL-6, IL-10 and SOD; CINC-1 and ICAM-1 expression; AMPKα and SIRT1 expression; ERK, JNK, p38, p65 and STAT3 activation |
| Pathways measured | AMPK signalling · SIRT1 / PGC-1α / biogenesis · MAPK signalling · Inflammation · Oxidative stress |
| Research areas | Lung · Inflammation & immunity |
| Evidence tier | C — Animal in vivo |
| Publication types | Journal Article |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- Mammalian
- Sample size
- Not reported
- Controls
- Limited
- Outcome validity
- Surrogate
- Support for its own conclusion
- Moderate
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.