Study record
Mitochondrial-Derived Peptide MOTS-c Attenuates Vascular Calcification and Secondary Myocardial Remodeling via Adenosine Monophosphate-Activated Protein Kinase Signaling Pathway
Wei M, Gan L, Liu Z et al. · Cardiorenal Med · 2020
AnimalMOTS-c administeredEvidence tier C
What this study reported
In rats with vitamin D3 plus nicotine-induced vascular calcification, MOTS-c treatment was associated with reduced calcification. Phosphorylated AMPK increased and AT-1 and ET-B receptor expression decreased after MOTS-c treatment.
Limitations
Males only in a single chemically induced model; group sizes not reported; AMPK involvement is correlative, with no inhibitor experiment described.
Study record
| Study model | Animal study (in vivo) |
|---|---|
| Substance studied | MOTS-c administeredSynthetic MOTS-c was given to cells, animals or people. |
| Species | rat |
| System studied | Male Sprague-Dawley rats with vitamin D3 plus nicotine-induced vascular calcification |
| Population | Not reported |
| Design | Controlled animal experiment |
| Sample size as reported | Not reported |
| Control group | vitamin D3 plus nicotine rats not given MOTS-c (implied) |
| Route (data field only) | Not reported |
| Endpoints measured | vascular calcification; blood pressure and heart rate; echocardiography; AMPK phosphorylation; AT-1 and ET-B receptor expression |
| Pathways measured | AMPK signalling |
| Research areas | Cardiovascular |
| Evidence tier | C — Animal in vivo |
| Publication types | Journal Article, Research Support, Non-U.S. Gov't |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- Mammalian
- Sample size
- Not reported
- Controls
- Limited
- Outcome validity
- Surrogate
- Support for its own conclusion
- Weak
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.