Study record
Reduced skeletal muscle expression of mitochondrial-derived peptides humanin and MOTS-C and Nrf2 in chronic kidney disease
Liu C, Gidlund EK, Witasp A et al. · Am J Physiol Renal Physiol · 2019
Human obs.Endogenous MOTS-c measuredEvidence tier B
What this study reported
Found lower MOTS-c in both skeletal muscle and serum of patients with stage 5 CKD than in controls, whereas circulating humanin was higher and muscle humanin lower. Reduced muscle MDP levels were associated with lower mitochondrial density and evidence of oxidative stress.
Limitations
Cross-sectional comparison; sample size not reported in the abstract; restricted to advanced CKD.
Study record
| Study model | Human observational |
|---|---|
| Substance studied | Endogenous MOTS-c measuredNaturally occurring MOTS-c was measured; nothing was given. |
| Species | human |
| System studied | Skeletal muscle and serum from patients with stage 5 chronic kidney disease and age-matched controls |
| Population | patients with stage 5 chronic kidney disease and age-matched controls with normal renal function |
| Design | Case-control study |
| Sample size as reported | Not reported |
| Control group | age-matched controls with normal renal function |
| Route (data field only) | Not reported |
| Endpoints measured | skeletal muscle MOTS-c and humanin protein; serum MOTS-c and humanin; mitochondrial density; oxidative stress markers; circulating TNF |
| Pathways measured | NRF2 / antioxidant response · Oxidative stress · Inflammation |
| Research areas | Kidney · Skeletal muscle · Aging · Mitochondrial biology |
| Evidence tier | B — Other human study |
| Publication types | Journal Article |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- Human
- Sample size
- Not reported
- Controls
- Appropriate
- Outcome validity
- Validated biomarker
- Support for its own conclusion
- Moderate
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.