Study record
MOTS-c: A Mitochondrial-Encoded Regulator of the Nucleus
Benayoun BA, Lee C · Bioessays · 2019
ReviewSeveralEvidence tier R
What this study reported
Reviewed evidence that MOTS-c can translocate to the nucleus upon metabolic stress such as glucose restriction and oxidative stress and regulate adaptive nuclear gene expression. Proposed that coevolved mitochondrial and nuclear genomes cross-regulate each other.
Limitations
Narrative review with a hypothesis component, relying mainly on cell-culture evidence.
Study record
| Study model | Review |
|---|---|
| Substance studied | SeveralMore than one of these is central to the paper (common for reviews). |
| Species | Not reported |
| System studied | Review of MOTS-c as a mitochondrial-encoded regulator of nuclear gene expression |
| Population | Not reported |
| Design | Narrative review / hypothesis |
| Sample size as reported | Not reported |
| Control group | Not reported |
| Route (data field only) | Not reported |
| Endpoints measured | nuclear translocation; adaptive nuclear gene expression |
| Pathways measured | Nuclear translocation · Oxidative stress |
| Research areas | Mitochondrial biology |
| Evidence tier | R — Review (context, not evidence) |
| Publication types | Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- n/a
- Sample size
- n/a
- Controls
- n/a
- Outcome validity
- n/a
- Support for its own conclusion
- n/a
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.