Study record
MOTS-c inhibits Osteolysis in the Mouse Calvaria by affecting osteocyte-osteoclast crosstalk and inhibiting inflammation
Yan Z, Zhu S, Wang H et al. · Pharmacol Res · 2019
AnimalMOTS-c administeredEvidence tier CAlso: Cell study (in vitro)
What this study reported
In a mouse particle-induced calvarial osteolysis model, MOTS-c treatment was associated with less bone erosion and inflammation. In culture, MOTS-c increased the OPG/RANKL ratio in osteocytes and reduced particle-triggered STAT1 and NF-κB phosphorylation in bone marrow macrophages, effects blocked by promoting ROS or suppressing PGC-1α via AMPK repression.
Limitations
Males only in a single implant-particle model; group sizes not reported in the abstract.
Study record
| Study model | Animal study (in vivo) |
|---|---|
| Substance studied | MOTS-c administeredSynthetic MOTS-c was given to cells, animals or people. |
| Species | mouse |
| System studied | Male C57BL/6 mice with UHMWPE particle-induced calvarial osteolysis; osteocytes and primary bone marrow macrophages |
| Population | Not reported |
| Design | Controlled animal experiment with cell culture experiments |
| Sample size as reported | Not reported |
| Control group | particle-challenged mice not given MOTS-c (implied); ROS promotion and AMPK repression experiments |
| Route (data field only) | Not reported |
| Endpoints measured | bone erosion; inflammation; OPG/RANKL ratio; osteoclastogenesis; STAT1 and NF-κB phosphorylation |
| Pathways measured | Inflammation · AMPK signalling · SIRT1 / PGC-1α / biogenesis · Oxidative stress |
| Research areas | Bone · Inflammation & immunity |
| Evidence tier | C — Animal in vivo |
| Publication types | Journal Article, Research Support, Non-U.S. Gov't |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Direct
- Model applicability
- Mammalian
- Sample size
- Not reported
- Controls
- Appropriate
- Outcome validity
- Surrogate
- Support for its own conclusion
- Moderate
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.