Study record
The role of mitochondria-derived peptides in cardiovascular disease: Recent updates
Yang Y, Gao H, Zhou H et al. · Biomed Pharmacother · 2019
ReviewSeveralEvidence tier R
What this study reported
Reviewed relationships between mitochondria-derived peptides, including MOTS-c, and cardiovascular risk factors, myocardial ischaemia, reperfusion injury, fibrosis and coronary microcirculatory dysfunction. The authors frame MDPs as candidate biomarkers or research targets in cardiovascular disease.
Limitations
Narrative review covering several peptides; MOTS-c-specific evidence is not separated in the abstract.
Study record
| Study model | Review |
|---|---|
| Substance studied | SeveralMore than one of these is central to the paper (common for reviews). |
| Species | Not reported |
| System studied | Review of mitochondria-derived peptides (humanin, MOTS-c, SHLP1-6) in cardiovascular disease |
| Population | Not reported |
| Design | Narrative review |
| Sample size as reported | Not reported |
| Control group | Not reported |
| Route (data field only) | Not reported |
| Endpoints measured | cardiovascular risk factors; myocardial ischaemia-reperfusion injury; myocardial fibrosis; coronary microcirculatory dysfunction |
| Pathways measured | Oxidative stress · Apoptosis · Inflammation |
| Research areas | Cardiovascular |
| Evidence tier | R — Review (context, not evidence) |
| Publication types | Journal Article, Review |
Appraisal
Each dimension is recorded separately and never combined into a single score. A study can be well controlled and still tell you little about people.
- Relevance to MOTS-c
- Indirect
- Model applicability
- n/a
- Sample size
- n/a
- Controls
- n/a
- Outcome validity
- n/a
- Support for its own conclusion
- n/a
Provenance
- Bibliographic fields retrieved from PubMed E-utilities efetch (title, journal, date, authors, DOI) on 2026-11-11.
- Annotated from the published abstract.
- Editorial review: approved (2026-11-11).
- Classification follows the site methodology; the record describes the study, not what MOTS-c does in people.